Interleukin 6
mammalian protein found in Homo sapiens
ಇದರ ಭಾಗವಾಗಿದೆ
interleukin-6[೧೩]
four-helical cytokine-like, core[೧೩]
Interleukin-6/GCSF/MGF, conserved site, protein family[೧೪]
found in taxon
Homo sapiens[೧೧]
encoded by
IL6[೧೧]
molecular function
cell component
biological process
positive regulation of DNA-binding transcription factor activity[೫೧]
determination method or standard: IDA
positive regulation of NF-kappaB transcription factor activity[೪೮]
determination method or standard: IDA
regulation of vascular endothelial growth factor production[೫೪]
determination method or standard: IDA
positive regulation of type B pancreatic cell apoptotic process[೫೫]
determination method or standard: TAS
positive regulation of cell population proliferation[೫೬][೨೨]
determination method or standard: IDA, IMP
positive regulation of tyrosine phosphorylation of STAT protein[೨೩][೫೯]
determination method or standard: IDA
positive regulation of transcription, DNA-templated[೬೧][೬೨][೫೧]
determination method or standard: IDA, IMP
positive regulation of transcription by RNA polymerase II[೧೬][೪೪][೬೩][೬೪]
determination method or standard: IDA, ISS
negative regulation of interleukin-1-mediated signaling pathway[೧೬]
determination method or standard: ISS
exact match
ಭಾಗವನ್ನು ಹೊಂದಿದೆ
Interleukin-6/GCSF/MGF, conserved site[೧೩]
Reference
- ↑ Freebase Data Dumps, ೨೮ ಅಕ್ಟೋಬರ್ 2013
- ↑ ೨.೦ ೨.೧ ೨.೨ ೨.೩ ೨.೪ NCBI Gene, ೩೦ ಮೇ 2020, 3569
- ↑ ೩.೦೦ ೩.೦೧ ೩.೦೨ ೩.೦೩ ೩.೦೪ ೩.೦೫ ೩.೦೬ ೩.೦೭ ೩.೦೮ ೩.೦೯ P05231, ೯ ಆಗಸ್ಟ್ 2016, ಆಂಗ್ಲ, UniProt
- ↑ Ensembl Release 99, ENSP00000385675
- ↑ Ensembl Release 99, ENSP00000258743
- ↑ Ensembl Release 99, ENSP00000384928
- ↑ Ensembl Release 99, ENSP00000385043
- ↑ Ensembl Release 99, ENSP00000385227
- ↑ Ensembl Release 99, ENSP00000385718
- ↑ Ensembl Release 99, ENSP00000405150
- ↑ ೧೧.೦ ೧೧.೧ ೧೧.೨ ೧೧.೩ UniProt, ೧೩ ನವೆಂಬರ್ 2019, P05231
- ↑ OpenAlex, ೨೬ ಜನವರಿ 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
- ↑ ೧೩.೦ ೧೩.೧ ೧೩.೨ InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P05231
- ↑ inferred from protein domain or family
- ↑ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor, GOA, NAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ ೧೬.೦ ೧೬.೧ ೧೬.೨ ೧೬.೩ ೧೬.೪ ೧೬.೫ ೧೬.೬ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, GOA, ISS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ ೧೭.೦ ೧೭.೧ ೧೭.೨ ೧೭.೩ ೧೭.೪ GOA, ೨೭ ಮಾರ್ಚ್ 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, IEA
- ↑ ೧೮.೦ ೧೮.೧ ೧೮.೨ ೧೮.೩ InterPro, ೨೭ ಮಾರ್ಚ್ 2018, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ ೧೯.೦ ೧೯.೧ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ ೨೦.೦ ೨೦.೧ ೨೦.೨ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ Proteome Inc., ೨೭ ಮಾರ್ಚ್ 2018, Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6), GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ ೨೨.೦ ೨೨.೧ ೨೨.೨ ೨೨.೩ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Molecular cloning and expression of an IL-6 signal transducer, gp130, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ ೨೩.೦ ೨೩.೧ ೨೩.೨ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ Proteome Inc., ೨೭ ಮಾರ್ಚ್ 2018, Loss of IL-6 receptor expression in cervical carcinoma cells inhibits autocrine IL-6 stimulation: abrogation of constitutive monocyte chemoattractant protein-1 production, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ Marked cell-type-specific differences in glycosylation of human interleukin-6, GOA, ೨೭ ಮಾರ್ಚ್ 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, NAS
- ↑ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ IntAct protein interaction database, ೨೭ ಮಾರ್ಚ್ 2018, Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ IntAct protein interaction database, ೨೭ ಮಾರ್ಚ್ 2018, Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ IntAct protein interaction database, ೨೭ ಮಾರ್ಚ್ 2018, A human protein-protein interaction network: a resource for annotating the proteome, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ IntAct protein interaction database, ೨೭ ಮಾರ್ಚ್ 2018, Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ IntAct protein interaction database, ೨೭ ಮಾರ್ಚ್ 2018, Structural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane Complex, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ ೩೨.೦ ೩೨.೧ ೩೨.೨ ೩೨.೩ ೩೨.೪ Reactome, ೨೭ ಮಾರ್ಚ್ 2018, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ ೩೫.೦ ೩೫.೧ ೩೫.೨ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Interleukin 6 induces the expression of vascular endothelial growth factor, GOA, IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription, GOA, ೨೭ ಮಾರ್ಚ್ 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, IDA
- ↑ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Platelet activation induced by interleukin-6: evidence for a mechanism involving arachidonic acid metabolism, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin, GOA, IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ ೪೦.೦ ೪೦.೧ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling, GOA, NAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6, GOA, IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ ೪೨.೦ ೪೨.೧ ೪೨.೨ ೪೨.೩ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ ೪೩.೦ ೪೩.೧ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes, GOA, NAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ ೪೪.೦ ೪೪.೧ ೪೪.೨ ೪೪.೩ Mouse Genome Informatics, ೨೭ ಮಾರ್ಚ್ 2018, Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Synergistic activation of human T cells by interleukin 1 and interleukin 6, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ ೪೬.೦ ೪೬.೧ ೪೬.೨ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ ೪೭.೦ ೪೭.೧ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ ೪೮.೦ ೪೮.೧ ೪೮.೨ ೪೮.೩ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ ೪೯.೦ ೪೯.೧ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE), GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor, GOA, IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ ೫೧.೦ ೫೧.೧ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ ೫೨.೦ ೫೨.೧ Interleukin-6 suppression of neutrophil apoptosis is neutrophil concentration dependent, GOA, ೨೭ ಮಾರ್ಚ್ 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, IDA
- ↑ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Interleukin 6 induces the expression of vascular endothelial growth factor, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Interleukin-6 regulates pancreatic alpha-cell mass expansion, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Interleukin-6 regulates pancreatic alpha-cell mass expansion, GOA, IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ Both Stat3-activation and Stat3-independent BCL2 downregulation are important for interleukin-6-induced apoptosis of 1A9-M cells, GOA, ೨೭ ಮಾರ್ಚ್ 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, IDA
- ↑ Gene Ontology Consortium, ೨೭ ಮಾರ್ಚ್ 2018, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ ೫೯.೦ ೫೯.೧ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ Proteome Inc., ೨೭ ಮಾರ್ಚ್ 2018, Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma, GOA, ೨೭ ಮಾರ್ಚ್ 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, IMP
- ↑ B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma, GOA, ೨೭ ಮಾರ್ಚ್ 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, IDA
- ↑ ೬೩.೦ ೬೩.೧ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ ೬೪.೦ ೬೪.೧ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ Mouse Genome Informatics, ೨೭ ಮಾರ್ಚ್ 2018, SASH1 is a scaffold molecule in endothelial TLR4 signaling, GOA, IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ GOA, ೨೭ ಮಾರ್ಚ್ 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ISS
- ↑ ೬೮.೦ ೬೮.೧ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ British Heart Foundation, ೨೭ ಮಾರ್ಚ್ 2018, Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells, GOA, IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ↑ Identifiers.org