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Interleukin 2

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mammalian protein found in Homo sapiens

media legend: Structure cristalline de l'IL-2 telle que publiée dans la Protein Data Bank

External resources

Freebase ಐಡಿ
/m/047sv6[೧]
Microsoft Academic ID
2777371288
2910973595
RefSeq protein ID
NP_000577[೨]
PDB structure ID
1IRL[೩]
1M47[೩]
1M48[೩]
1M49[೩]
1M4A[೩]
1M4B[೩]
1M4C[೩]
1NBP[೩]
1PW6[೩]
1PY2[೩]
1QVN[೩]
1Z92[೩]
2B5I[೩]
2ERJ[೩]
3QAZ[೩]
3QB1[೩]
3INK[೩]
4NEJ[೩]
4NEM[೩]
BNCF Thesaurus ID
4201[೪]
OpenAlex ID
C2777371288[೫]
C2908885563[೫]
UniProt protein ID
P60568[೬]
Ensembl protein ID
ENSP00000226730[೭]

ಉದಾಹರಣೆಗೆ

ಪ್ರೋಟೀನ್[೬]

ಇದರ ಭಾಗವಾಗಿದೆ

interleukin-2[೮]
four-helical cytokine-like, core[೮]
Interleukin-2, conserved site, protein family[೯]

found in taxon

Homo sapiens[೬]

encoded by

IL2[೬]

molecular function

cytokine activity[೧೦][೧೧][೧೨][೧೩]

determination method: IDA, IEA

interleukin-2 receptor binding[೧೪][೧೫][೧೧][೧೬]

determination method: IDA, IEA, TAS

glycosphingolipid binding[೧೧]

determination method: IEA

kinase activator activity[೧೭]

determination method: TAS

growth factor activity[೧೭][೧೦][೧೫]

determination method: IEA, TAS

kappa-type opioid receptor binding[೧೧]

determination method: IEA

carbohydrate binding[೧೧]

determination method: IEA

protein binding[೧೮][೧೯][೨೦]

determination method: IPI

cell component

extracellular region[೨೧][೧೦][೧೫]

determination method: IEA, TAS

intracellular anatomical structure[೨೨]

determination method: IEA

extracellular space[೨೩][೧೦][೧೧]

determination method: IEA, TAS

biological process

positive regulation of T cell differentiation[೧೧]

determination method: IEA

negative regulation of protein phosphorylation[೧೧]

determination method: IEA

G protein-coupled receptor signaling pathway[೧೧]

determination method: IEA

positive regulation of protein phosphorylation[೧೧]

determination method: IEA

positive regulation of inflammatory response[೨೪]

determination method: IC

adaptive immune response[೧೦]

determination method: IEA

negative regulation of heart contraction[೧೧]

determination method: IEA

immune system process[೧೦]

determination method: IEA

positive regulation of cytosolic calcium ion concentration[೧೧]

determination method: IEA

positive regulation of regulatory T cell differentiation[೧೧]

determination method: IEA

cell-cell signaling[೧೭]

determination method: TAS

positive regulation of interferon-gamma production[೧೧]

determination method: IEA

natural killer cell activation[೧೭]

determination method: TAS

negative regulation of apoptotic process[೧೭]

determination method: TAS

positive regulation of dendritic spine development[೧೧]

determination method: IEA

negative regulation of lymphocyte proliferation[೧೧]

determination method: IEA

MAPK cascade[೨೧]

determination method: TAS

regulation of T cell homeostatic proliferation[೧೧]

determination method: IEA

T cell differentiation[೧೭]

determination method: TAS

positive regulation of cell growth[೧೭]

determination method: TAS

protein kinase C-activating G protein-coupled receptor signaling pathway[೧೧]

determination method: IEA

cell adhesion[೨೫]

determination method: TAS

positive regulation of B cell proliferation[೨೬]

determination method: IDA

positive regulation of tissue remodeling[೨೪]

determination method: IC

positive regulation of T cell proliferation[೧೧]

determination method: IEA

immune response[೨೭][೧೫]

determination method: TAS, IEA

positive regulation of cell population proliferation[೧೭]

determination method: TAS

extrinsic apoptotic signaling pathway in absence of ligand[೧೧]

determination method: IEA

negative regulation of B cell apoptotic process[೨೬]

determination method: IDA

positive regulation of isotype switching to IgG isotypes[೧೧]

determination method: IEA

positive regulation of interleukin-17 production[೨೮]

determination method: IDA

response to ethanol[೧೧]

determination method: IEA

negative regulation of inflammatory response[೧೧]

determination method: IEA

positive regulation of transcription by RNA polymerase II[೧೧]

determination method: IEA

positive regulation of activated T cell proliferation[೧೧][೧೨][೧೩]

determination method: IDA, IEA

negative regulation of T-helper 17 cell differentiation[೧೧]

determination method: IEA

leukocyte activation involved in immune response[೨೯]

determination method: IDA

positive regulation of tyrosine phosphorylation of STAT protein[೧೧][೩೦]

determination method: IDA, IEA

regulation of regulatory T cell differentiation[೨೧]

determination method: TAS

regulation of signaling receptor activity[೩೧]

determination method: IEA

cytokine-mediated signaling pathway[೨೧]

determination method: TAS

interleukin-2-mediated signaling pathway[೨೧]

determination method: TAS

positive regulation of kinase activity[೩೧]

determination method: IEA

Gene Atlas image

exact match

http://purl.uniprot.org/uniprot/P60568[೩೨]

ಭಾಗವನ್ನು ಹೊಂದಿದೆ

Interleukin-2, conserved site[೮]

Reference

  1. ↑ Freebase Data Dumps, ೨೮ ಅಕ್ಟೋಬರ್ 2013
  2. ↑ NCBI Gene, ೩೦ ಮೇ 2020, 3558
  3. ↑ ೩.೦೦ ೩.೦೧ ೩.೦೨ ೩.೦೩ ೩.೦೪ ೩.೦೫ ೩.೦೬ ೩.೦೭ ೩.೦೮ ೩.೦೯ ೩.೧೦ ೩.೧೧ ೩.೧೨ ೩.೧೩ ೩.೧೪ ೩.೧೫ ೩.೧೬ ೩.೧೭ ೩.೧೮ P60568, ೪ ಆಗಸ್ಟ್ 2016, UniProt, ಆಂಗ್ಲ
  4. ↑ National Central Library of Florence
  5. ↑ ೫.೦ ೫.೧ OpenAlex, ೨೬ ಜನವರಿ 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
  6. ↑ ೬.೦ ೬.೧ ೬.೨ ೬.೩ UniProt, ೧೩ ನವೆಂಬರ್ 2019, P60568
  7. ↑ Ensembl Release 99, ENSP00000226730
  8. ↑ ೮.೦ ೮.೧ ೮.೨ InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P60568
  9. ↑ inferred from protein domain or family
  10. ↑ ೧೦.೦ ೧೦.೧ ೧೦.೨ ೧೦.೩ ೧೦.೪ ೧೦.೫ IEA, ೮ ಏಪ್ರಿಲ್ 2019, P60568, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568, UniProt
  11. ↑ ೧೧.೦೦ ೧೧.೦೧ ೧೧.೦೨ ೧೧.೦೩ ೧೧.೦೪ ೧೧.೦೫ ೧೧.೦೬ ೧೧.೦೭ ೧೧.೦೮ ೧೧.೦೯ ೧೧.೧೦ ೧೧.೧೧ ೧೧.೧೨ ೧೧.೧೩ ೧೧.೧೪ ೧೧.೧೫ ೧೧.೧೬ ೧೧.೧೭ ೧೧.೧೮ ೧೧.೧೯ ೧೧.೨೦ ೧೧.೨೧ ೧೧.೨೨ ೧೧.೨೩ ೧೧.೨೪ ೧೧.೨೫ ೧೧.೨೬ IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568, ೮ ಏಪ್ರಿಲ್ 2019, Ensembl genome database project, GOA
  12. ↑ ೧೨.೦ ೧೨.೧ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568, ೮ ಏಪ್ರಿಲ್ 2019, Mouse Genome Informatics, Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells, GOA
  13. ↑ ೧೩.೦ ೧೩.೧ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568, ೮ ಏಪ್ರಿಲ್ 2019, Mouse Genome Informatics, Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting, GOA
  14. ↑ TAS, ೮ ಏಪ್ರಿಲ್ 2019, P60568, Similarities between interleukin-2 receptor number and affinity on activated B and T lymphocytes, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568, UniProt
  15. ↑ ೧೫.೦ ೧೫.೧ ೧೫.೨ ೧೫.೩ IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568, ೮ ಏಪ್ರಿಲ್ 2019, InterPro, GOA
  16. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568, ೮ ಏಪ್ರಿಲ್ 2019, Mouse Genome Informatics, Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor, GOA
  17. ↑ ೧೭.೦ ೧೭.೧ ೧೭.೨ ೧೭.೩ ೧೭.೪ ೧೭.೫ ೧೭.೬ ೧೭.೭ TAS, ೮ ಏಪ್ರಿಲ್ 2019, P60568, The IL-2 receptor complex: its structure, function, and target genes, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568, UniProt
  18. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568, ೮ ಏಪ್ರಿಲ್ 2019, IntAct protein interaction database, Exploiting a natural conformational switch to engineer an interleukin-2 'superkine', GOA
  19. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568, ೮ ಏಪ್ರಿಲ್ 2019, IntAct protein interaction database, Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor, GOA
  20. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568, ೮ ಏಪ್ರಿಲ್ 2019, IntAct protein interaction database, Hot-spot mimicry of a cytokine receptor by a small molecule, GOA
  21. ↑ ೨೧.೦ ೨೧.೧ ೨೧.೨ ೨೧.೩ ೨೧.೪ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568, ೮ ಏಪ್ರಿಲ್ 2019, Reactome, GOA
  22. ↑ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P60568&geneProductId=UniProtKB:P60568, ೧೦ ಸೆಪ್ಟೆಂಬರ್ 2018, Gene Ontology Consortium, GOA
  23. ↑ TAS, ೮ ಏಪ್ರಿಲ್ 2019, P60568, T-cell growth factor: complete nucleotide sequence and organization of the gene in normal and malignant cells, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568, UniProt
  24. ↑ ೨೪.೦ ೨೪.೧ IC, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568, ೮ ಏಪ್ರಿಲ್ 2019, British Heart Foundation, Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells, GOA
  25. ↑ TAS, ೮ ಏಪ್ರಿಲ್ 2019, P60568, Induction of interactions between CD44 and hyaluronic acid by a short exposure of human T cells to diverse pro-inflammatory mediators, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568, UniProt
  26. ↑ ೨೬.೦ ೨೬.೧ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568, ೮ ಏಪ್ರಿಲ್ 2019, Mouse Genome Informatics, The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression, GOA
  27. ↑ TAS, ೮ ಏಪ್ರಿಲ್ 2019, P60568, Severe combined immunodeficiency due to a specific defect in the production of interleukin-2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568, UniProt
  28. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568, ೮ ಏಪ್ರಿಲ್ 2019, British Heart Foundation, Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells, GOA
  29. ↑ IDA, ೮ ಏಪ್ರಿಲ್ 2019, P60568, HMGN2: a novel antimicrobial effector molecule of human mononuclear leukocytes?, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568, UniProt
  30. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568, ೮ ಏಪ್ರಿಲ್ 2019, British Heart Foundation, IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12, GOA
  31. ↑ ೩೧.೦ ೩೧.೧ IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568, ೮ ಏಪ್ರಿಲ್ 2019, Gene Ontology Consortium, GOA
  32. ↑ Identifiers.org
"https://kn.wikipedia.org/wiki/ವಿಶೇಷ:AboutTopic/Q410130" ಇಂದ ಪಡೆಯಲ್ಪಟ್ಟಿದೆ